威斯康辛大学新闻

2022年3月8日,

O-pH, 一个新的凤凰彩票官网牙科工具原型, can spot the acidic conditions that lead to cavities

威斯康辛大学新闻

病人正在接受牙科检查

A new 凤凰彩票官网 dental tool prototype uses a low-power light system to monitor reactions with a florescent dye solution to find where teeth enamel is most at risk from the acidity of plaque.凤凰彩票官网 and IEEE Xplore/Creative Commons

You and your dentist have a lot of tools and techniques for stopping cavities, but detecting the specific chemical conditions that can lead to cavities and then preventing them from ever getting started is much harder. 现在,在一个新的 研究, 凤凰彩票官网 researchers have shown that a dental tool they created can measure the acidity built up by the bacteria in plaque that leads to cavities.

的 O-pH system is a prototype optical device that emits an LED light and measures the reactions of that light, 的荧光, with an FDA-approved chemical dye applied to teeth. 的 O-pH then produces a numerical reading of the pH, or acidity, of the plaque covering those teeth. Knowing how acidic the plaque is can tell dentists and patients what area of a tooth is most at risk of developing a cavity.

“Plaque has a lot of bacteria that produce acid when they interact with the sugar in our food,” said Manuja沙玛, lead author and a doctoral student in the UW 电气部门 & 计算机工程. “This acid is what causes the corrosion of the tooth surface and eventually cavities. So, if we can capture information about the acidic activity, we can get an idea of how bacteria are growing in the dental biofilm, 或斑块.”

牙科检查使用新工具

的 UW optical O-pH prototype can non-invasively measure the acidity of oral biofilm.凤凰彩票官网 and IEEE Xplore/Creative Commons

Sharma explained that not all bacteria in that biofilm are bad or will lead to cavities, so measuring the acidity of the environment can tell a dentist what they need to know about the threat of developing problems. That can limit the need to test for specific harmful bacteria, of which there can be a multitude.

来测试他们的设备, the researchers recruited 30 patients between the ages of 10 and 18, 平均年龄为15岁, 在凤凰彩票官网牙科学院 儿科牙科中心. 的 researchers chose kids for their 研究 in large part because the enamel on kids’ teeth is much thinner than that of adults, so getting early warning of acid erosion is even more important. To perform the measurements with the O-pH device, the researchers also recruited second- and third-year students in the dentistry school, 谁受教职员的指导.

这项检查是非侵入性的. 当染料涂在牙齿上时, at the end of a length of cord is the probe that transmits and collects light while hovering over the surface of a tooth (see photos). 的 collected light travels back to a central box that provides a pH reading. 的 conditions on the patients’ teeth were read several times before and after sugar rinses and other condition changes, such as pre- and post-professional dental cleaning.

Eric Seibel, senior author and research professor of mechanical engineering in the UW 工程学院, said the idea for adding the acidity test as a new clinical procedure came from envisioning that when a patient first sits in the dental chair, 在他们的牙齿清洁之前, “a dentist would rinse them with the tasteless fluorescent dye solution and then get their teeth optically scanned to look for high acid production areas where the enamel is getting demineralized.”

研究 was published in February in IEEE Transactions on Biomedical 工程. 的 research team reported that one limitation to their 研究 was being unable to consistently measure the same location on each tooth during each phase of testing. 为了解决这个问题, 特别是, the researchers are evolving their device to a version that produces images for dentists that instantly show the exact location of high acidity, 下一个蛀牙可能发生在哪里.

“We do need more results to show how effective it is for diagnosis, but it can definitely help us understand some of your oral health quantitatively,夏尔马说. “It can also help educate patients about the effects of sugar on the chemistry of plaque. 凤凰彩票平台APP下载可以向他们展示, 生活, 会发生什么, and that is an experience they’ll remember and say, OK, 细, 我需要少吃糖!”

合著者包括劳伦·李(Lauren Lee), UW 微生物学系; Matthew Carson, UW 人类光子学实验室; David Park, Se的, 弥迦书Bovenkamp, 杰斯公爵卡耶塔诺, 伊恩粗鲁的, 郑许, Alireza萨德尔的, UW 牙科学院; and Shwetak Patel, 威斯康辛大学电 & 计算机工程和保罗G. 艾伦计算机科学学院 & 工程. This research was funded by the National 科学 Foundation, 口腔健康监控, Institute of Translational Health 科学s; and the National Center for Advancing Translational 科学s of the National Institutes of Health.

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For more information, contact Seibel at eseibel@uw.edu.

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